期刊
EUROPEAN JOURNAL OF CANCER
卷 44, 期 12, 页码 1754-1760出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.05.010
关键词
cDNA microarrays; colorectal neoplasms; celecoxib cyclooxygenase 2 inhibitors; gene expression profiling
类别
资金
- NCI Cancer Center [P30 CA91842]
- NIH [U01GM63340]
Cancer cells treated with the cyclooxygenase-2 inhibitor celecoxib show growth inhibition and induced apoptosis. This study was conducted to determine if the same processes are relevant to celecoxib's effects on human colorectal adenocarcinomas treated in vivo. A cohort of 23 patients with primary colorectal adenocarcinomas was randomised to receive a 7-d course of celecoxib (400 mg b.i.d.) or no drug prior to surgical resection. Gene expression profiling was performed on resected adenocarcinomas from the cohort of patients. Using fold change (>1.5) and p-value (<0.05) cut-offs, 190 genes were differentially expressed between adenocarcinomas from patients receiving celecoxib and those that did not. The celecoxib pre-treated samples showed decreased expression levels in multiple genes involved in cellular lipid and glutathione metabolism; changes associated with diminished cellular proliferation. Celecoxib pre-treatment for 7 d in vivo is associated with alterations in colorectal adenocarcinoma gene expression which are suggestive of diminished cellular proliferation. (C) 2008 Elsevier Ltd. All rights reserved.
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