期刊
EUROPEAN JOURNAL OF CANCER
卷 44, 期 7, 页码 978-982出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.02.040
关键词
phase I trials; recruitment; limiting factors
类别
Aim: To identify factors that may prevent or delay patients referred for consideration of phase I studies from commencing such a study. Methods: A retrospective audit of phase I study referrals for the period 1st March to 31st August 2005 to the Drug Development Unit was performed. All reasons that led to either delay or recruitment failure were documented and analysed. Results: Data from 176 patients (105M/71F) were analysed. Median age at referral was 59 years and median performance status (PS) was 1. Of these, 56 (32%) were successfully recruited in a phase I trial. The median time from trial allocation to commencement of treatment was 4.8 weeks. Poor or deteriorating PS was the reason for delay or recruitment failure in 43 (35%) of non-recruited patients. Conclusions: Poor or deteriorating PS was the most common factor limiting accrual to phase I trials. Better patients' selection on this basis might improve recruitment rates. (c) 2008 Elsevier Ltd. All rights reserved.
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