期刊
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
卷 112, 期 7, 页码 2777-2781出版社
SPRINGER
DOI: 10.1007/s00421-011-2237-0
关键词
Endocannabinoids; Anandamide; 2-AG; Exercise; Sport
资金
- South Tyrolean Department of Health
- Siemens Medical Solutions, Munich, Germany
- Department of Anaesthesiology
- Department of Intensive Care Medicine of Brixen (Italy)
- Department of Intensive Care Medicine of Munich (Germany)
The effects of physical exercise stress on the endocannabinoid system in humans are almost unexplored. In this prospective study, we investigated in a crossover design and under field conditions at different altitudes the effects of physical exercise on the endocannabinoid system (ECS) in 12 trained healthy volunteers. For determination of alterations on the ECS three different protocols were analyzed: Protocol A (physical exercise at lower altitude) involved strenuous hiking below 2,100 m, whereas Protocol B (physical exercise by active ascent to high altitude) involved hiking up to 3,196 m, an accommodation at the cottage and a descent the next day. Protocol C (passive ascent) included a helicopter ascent to 3,196 m, an overnight stay at this altitude and a flight back to the base camp the following day. The cumulative hiked altitude in Protocol A and B was comparable ( 1,650 m). The blood EC concentrations of anandamide increased significantly in Protocol A/B from baseline (T0) 0.12 +/- A 0.01/0.16 +/- A 0.02 (mean +/- A SEM) to 0.27 +/- A 0.02/0.42 +/- A 0.02 after exercise (T1) (p < 0.05). Anandamide levels in Protocol C remained stable at 0.20 +/- A 0.02. We conclude that the ECS is activated upon strenuous exercise whereas the combination with hypoxic stress further increases its activity. The reduced partial pressure of oxygen at high altitude alone did not affect this system. In summary, physical exercise activates the endocannabinoid system, whereas the combination with high altitude enhances this activation. This discloses new perspectives to adaptation mechanisms to physical exercise.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据