期刊
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
卷 108, 期 1, 页码 191-195出版社
SPRINGER
DOI: 10.1007/s00421-009-1192-5
关键词
Advanced glycation end products; Aging; Carboxymethyl-lysine; Physical performance; Walking speed
资金
- National Institute on Aging [R01 AG027012, R56 AG027012, R01 AG029148]
- Intramural Research Program, National Institute on Aging, NIH
- NATIONAL INSTITUTE ON AGING [R01AG029148, R56AG027012, ZIAAG001050, R01AG027012] Funding Source: NIH RePORTER
Advanced glycation end products (AGEs) are bioactive molecules found in foods and generated endogenously in the body. AGEs induce cross-linking of collagen and increase the stiffness of skeletal muscle and cartilage. We characterized the relationship between a plasma AGE, carboxymethyl-lysine (CML), and slow walking speed (lowest quintile of walking speed) in older adults. Walking speed over a 4 m course was assessed in 944 adults, aged a parts per thousand yen65 years, in the InCHIANTI study, a population-based study of aging and mobility disability conducted in two towns in Tuscany, Italy. Participants in the highest quartile of plasma CML were at higher risk of slow walking speed (Odds Ratio [O.R.] 1.56, 95% Confidence Interval [C.I.] 1.02-2.38, P = 0.04) compared to those in the lower three quartiles of plasma CML in a logistic regression models adjusting for age, education, cognitive function, smoking, and chronic diseases. After exclusion of participants with diabetes, participants in the highest quartile of plasma CML were at higher risk of slow walking speed (O.R. 1.87, 95% C.I. 1.15-3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据