期刊
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
卷 108, 期 3, 页码 459-468出版社
SPRINGER
DOI: 10.1007/s00421-009-1232-1
关键词
Cardiac function; Blood lipids; Inflammatory cytokine; Cholinesterase-positive nerve; Muscarinic cholinergic (M-2) receptor
资金
- National Natural Science Foundation of China [30930105, 30873058, 30770785]
- National Basic Research Program of China [2007CB512005]
- CMB Distinguished Professorships [F510000/G16916404]
The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M-2) receptors expression in the heart was investigated in Sprague-Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M-2 receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M-2 receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M-2 receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M-2 receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.
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