期刊
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
卷 28, 期 1, 页码 39-44出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EJA.0b013e32834089cf
关键词
anaesthesia; blood pressure; cardiac output; fluid therapy; thoracoscopy; thoracotomy
资金
- Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National College of Medicine, Seoul, Korea
Background and objective Pulse pressure variation (PPV) is increasingly advocated as a predictor of fluid responsiveness in patients receiving mechanical ventilation. However, the ability of PPV has never been studied during one-lung ventilation (OLV). Therefore, we evaluated the value of PPV to predict fluid responsiveness in patients receiving conventional and protective OLV using receiver operating characteristic (ROC) analysis, respectively. Methods Forty-nine patients undergoing lung surgery requiring OLV were enrolled in this study. Patients were randomised either to group P [patients receiving protective OLV with tidal volume 6 ml kg(-1), inspired oxygen fraction (FIO2) of 0.5 and positive end-expiratory pressure (PEEP) of 5 cmH(2)O) or group C (patients receiving conventional OLV with tidal volume of 10 ml kg(-1), FIO2 of 1.0 and no PEEP). Following OLV, PPV and cardiac output were measured before and 12 min after fluid loading (7 ml kg(-1) hydroxyethyl starch 6%). Patients whose cardiac indices increased by at least 15% to fluid loading were defined as the responders. Results The areas under ROC curve for PPV were 0.857 (P = 0.006) in group P and 0.524 (P = 0.839) in group C, respectively. The optimal threshold value given by ROC analysis for PPV was 5.8% in group P. Conclusions PPV could predict fluid responsiveness only during protective OLV, but not conventional OLV. PPV would be helpful for fluid management in patients receiving protective OLV for lung surgery using thoracotomy. Eur J Anaesthesiol 2011;28:39-44 Published online 19 November 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据