期刊
ANNALS OF EPIDEMIOLOGY
卷 25, 期 7, 页码 512-518出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2015.03.007
关键词
Tea; Adult; Cardiovascular diseases/mortality; Respiratory diseases/mortality; Follow-up studies; Japan/epidemiology; Proportional hazards models
资金
- National Cancer Center Research and Development Fund [23-A-31[toku], 26-A-2]
- Ministry of Health, Labor and Welfare of Japan
- Health and Labor Sciences Research Expenses for Commission (Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus) [H26-005]
- Grants-in-Aid for Scientific Research [26253043] Funding Source: KAKEN
Purpose: We examined the association between green tea consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries, and other causes of death in a large-scale population-based cohort study in Japan. Methods: We studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green tea consumption and risk of all causes and major causes of mortality was assessed using the Cox proportional hazards regression model with adjustment for potential confounders. Results: Hazard ratios for all-cause mortality among men who consumed green tea compared with those who drank less than 1 cup/day were 0.96 (0.89-1.03) for 1-2 cups/day, 0.88 (0.82-0.95) for 3-4 cups/day, and 0.87 (0.81-0.94) for more than 5 cups/day (P for trend <.001). Corresponding hazard ratios for women were 0.90 (0.81-1.00), 0.87(0.79-0.96), and 0.83 (0.75-0.91; P for trend <.001). Green tea was inversely associated with mortality from heart disease in both men and women and mortality from cerebrovascular disease and respiratory disease in men. No association was found between green tea and total cancer mortality. Conclusions: This prospective study suggests that the consumption of green tea may reduce the risk of all-cause mortality and the three leading causes of death in Japan. (C) 2015 Elsevier Inc. All rights reserved.
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