期刊
ANNALS OF EPIDEMIOLOGY
卷 25, 期 11, 页码 803-810出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2015.08.002
关键词
Pesticides; Insecticides; Women; Lymphoma; Leukemia
资金
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C]
- NIH, National Institute of Environmental Health Sciences
Purpose: Relationships of farm history and insecticide exposure at home or work with lymphohematopoietic (LH) neoplasm risk were investigated in a large prospective cohort of US women. Methods: In questionnaires, women self-reported history living or working on a farm, personally mixing or applying insecticides, insecticide application in the home or workplace by a commercial service, and treating pets with insecticides. Relationships with non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLIKL), follicular lymphoma, plasma cell neoplasms, and myeloid leukemia were investigated using Cox proportional hazard models. Age and farming history were explored as effect modifiers. Results: The analysis included 76,493 women and 822 NHL cases. Women who ever lived or worked on a farm had 1.12 times the risk of NHL (95% confidence interval [Cl] = 0.95-1.32) compared to those who did not. Women who reported that a commercial service ever applied insecticides in their immediate surroundings had 65% higher risk of CLL/SLL (95% Cl = 1.15-2.38). Women aged less than 65 years who ever applied insecticides had 87% higher risk of DLBCL (95% Cl = 1.13-3.09). Conclusions: Insecticide exposures may contribute to risk of CLL/SLL and DLBCL Future studies should examine relationships of LH subtypes with specific types of household insecticides. (C) 2015 Elsevier Inc. All rights reserved.
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