期刊
EUROPEAN HEART JOURNAL
卷 39, 期 33, 页码 3135-3143出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehy418
关键词
Dementia; Cognitive decline; Orthostatic hypotension; Hypertension; Older adult
资金
- Australian Dementia Collaborative Research Centre
- National Institute of Health and Medical Research (NHMRC) [APP1102694]
- Dalhousie Medical Research Foundation
- Canadian Institutes of Health Research
- Canadian Frailty Network
- Fountain Family Research Fund of the Queen Elizabeth II Health Sciences Centre
- British Heart Foundation
- Servier International
Aims Systematically reviewing the literature found orthostatic hypotension (OH) to be associated with an increased risk of incident dementia but limited data were available in those at highest risk, the hypertensive oldest-old. Our aim was to analyse the relationship between OH and incident cognitive decline or dementia in this group and to synthesize the evidence base overall Method and results Participants aged >= 80 years, with hypertension, were from the Hypertension in the Very Elderly Trial (HYVET) cohort. Orthostatic hypotension was defined as a fall of >= 15mmHg in systolic and or >= 7mmHg in diastolic pressure after 2 min standing from a sitting position. Subclinical orthostatic hypotension with symptoms (SOH) was defined as a fall
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