期刊
EUROPEAN HEART JOURNAL
卷 35, 期 23, 页码 1515-U24出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehu163
关键词
Vascular calcifications; Monckeberg's media sclerosis; Vascular molecular biology and genetics; Vascular function
资金
- British Heart Foundation [RG/11/14/29056] Funding Source: researchfish
Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.
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