期刊
EUROPEAN HEART JOURNAL
卷 35, 期 30, 页码 2001-+出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehu205
关键词
Cardiovascular clinical trials; Patient-reported outcomes; Health-related quality of life
资金
- Medical Research Council
- Canadian Institutes for Health Research
- Servier
- Biotronik
- Medtronic
- Amgen
- Pfizer
- 3M Medica
- MEDA Pharma
- Bristol-Myers Squibb
- Cardiovascular Therapeutics
- OMRON
- Sanofi
- St Jude Medical
- German Federal Ministry for Education and Research
- Foundation Leducq
- German Research Foundation
- European Union
- British Heart Foundation
- MRC [MR/K025643/1] Funding Source: UKRI
- Medical Research Council [MR/K025643/1] Funding Source: researchfish
Patient-reported outcomes (PROs), such as symptoms, health-related quality of life (HRQOL), or patient perceived health status, are reported directly by the patient and are powerful tools to inform patients, clinicians, and policy-makers about morbidity and 'patient suffering', especially in chronic diseases. Patient-reported outcomes provide information on the patient experience and can be the target of therapeutic intervention. Patient-reported outcomes can improve the quality of patient care by creating a holistic approach to clinical decision-making; however, PROs are not routinely used as key outcome measures in major cardiovascular clinical trials. Thus, limited information is available on the impact of cardiovascular therapeutics on PROs to guide patient-level clinical decision-making or policy-level decision-making. Cardiovascular clinical research should shift its focus to include PROs when evaluating the efficacy of therapeutic interventions, and PRO assessments should be scientifically rigorous. The European Society of Cardiology and other professional societies can take action to influence the uptake of PRO data in the research and clinical communities. This process of integrating PRO data into comprehensive efficacy evaluations will ultimately improve the quality of care for patients across the spectrum of cardiovascular disease.
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