期刊
EUROPEAN HEART JOURNAL
卷 35, 期 31, 页码 2106-2114出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehu151
关键词
Circulating microRNA; Myocardial infarction; Unstable angina pectoris; Acute myocardial infarction; Diagnosis
资金
- European Union Seventh Framework Programme (FP7) [HEALTH-F2-2011-278913]
- Brahms AG
- Abbott Diagnostics
- Swiss National Science Foundation
- Swiss Heart Foundation
- Department of Internal Medicine
- University Hospital Basel
- University Basel
- Abbott
- Brahms
- Roche
- Siemens
- government of Rheinland-Pfalz [AZ 961-386261/733]
- Wissen schafft Zukunft
- 'Schwerpunkt Vaskulare Pravention' of the University Medical Center Mainz
- Boehringer Ingelheim
- PHILIPS medical systems
- Gutenberg Health Study
- MAIFOR program of the University Medical Center Mainz
- National Genome Network 'NGFNplus' by the federal Ministry of Education and Research, Germany [01GS0833, 01GS0831, A3/D1]
Aims While cardiac troponin measurements have significantly improved the early diagnosis of myocardial infarction, the timely biomarker-based diagnosis of unstable angina pectoris (UAP) remains a major unmet clinical challenge. The aim of this study was to assess levels of circulating microRNAs (miRNAs) as possible novel biomarkers in patients with UAP. Methods and results A three-phase approach was conducted, comprising (i) profiling of miRNAs in patients with UAP and controls groups; (ii) replication of significant miRNAs in an independent patient cohort, (iii) validation of a multi-miRNAs panel in a third cohort. Out of 25 miRNAs selected for replication, 8 miRNAs remained significantly associated with UAP. In a validation phase, a miRNA panel including miR-132, miR-150, and miR-186 showed the highest discriminatory power [area under the receiver-operating-characteristic curve (AUC): 0.91; CI: 0.84-0.98]. Conclusion Using a profiling-replication-validation model, we identified eight miRNAs, which may facilitate the diagnosis of UAP.
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