期刊
EUROPEAN HEART JOURNAL
卷 34, 期 30, 页码 2346-+出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/eht100
关键词
Cardiovascular magnetic resonance imaging; Microvascular obstruction; Intramyocardial haemorrhage; Histopathology; Reperfusion injury
Lack of gadolinium-contrast wash-in on first-pass perfusion imaging, early gadolinium-enhanced imaging, or late gadolinium-enhanced (LGE) cardiovascular magnetic resonance (CMR) imaging after revascularized ST-elevation myocardial infarction (STEMI) is commonly referred to as microvascular obstruction (MVO). Additionally, T2-weighted imaging allows for the visualization of infarct-related oedema and intramyocardial haemorrhage (IMH) within the infarction. However, the exact histopathological correlate of the contrast-devoid core and its relation to IMH is unknown. In eight Yorkshire swine, the circumflex coronary artery was occluded for 75 min by a balloon catheter. After 7 days, CMR with cine imaging, T2-weighted turbospinecho, and LGE was performed. Cardiovascular magnetic resonance images were compared with histological findings after phosphotungstic acidhaematoxylin and anti-CD31/haematoxylin staining. These findings were compared with CMR findings in 27 consecutive PCI-treated STEMI patients, using the same scanning protocol. In the porcine model, the infarct core contained extensive necrosis and erythrocyte extravasation, without intact vasculature and hence, no MVO. The surroundingugadolinium-enhanceduarea contained granulation tissue, leucocyte infiltration, and necrosis with morphological intact microvessels containing microthrombi, without erythrocyte extravasation. Areas with IMH (median size 1.92 [0.365.25] cm(3)) and MVO (median size 2.19 [0.404.58] cm(3)) showed close anatomic correlation [intraclass correlation coefficient (ICC) 0.85, r 0.85, P 0.03]. Of the 27 STEMI patients, 15 had IMH (median size 6.60 [2.499.79] cm(3)) and 16 had MVO (median size 4.31 [1.057.57] cm(3)). Again, IMH and MVO showed close anatomic correlation (ICC 0.87, r 0.93, P 0.001). The contrast-devoid core of revascularized STEMI contains extensive erythrocyte extravasation with microvascular damage. Attenuating the reperfusion-induced haemorrhage may be a novel target in future adjunctive STEMI treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据