期刊
EUROPEAN HEART JOURNAL
卷 35, 期 31, 页码 2115-+出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/eht481
关键词
Atherosclerosis; Chemokines; Myocardial infarction; CXCL12
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902]
- University of Pennsylvania [CTRC CTSA UL1 RR-024134]
- Johns Hopkins University [UL1 RR-025005]
- University of Maryland [GCRC M01 RR-16500]
- Clinical and Translational Science Collaborative of Cleveland from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health [UL1TR000439]
- NIH roadmap for Medical Research
- Michigan Institute for Clinical and Health Research (MICHR) [UL1RR024986]
- University of Illinois at Chicago [CTSA UL1RR029879]
- Clinical and Translational Research, Education, and Commercialization Project (CTRECP)
- Kaiser NIH/NCRR [UCSF-CTSI UL1 RR-024131]
- National Institutes of Health Intramural Award [HL-Z0000]
- Department of Veterans Affairs Health Services Research and Development Service Award
- [R01-DK071224]
- [K24-DK002651]
- [R01-HL107196]
- [K24-HL107643]
- [R01-DK090505]
- [U01-HL108636]
- [R01-HL113147]
Aims Genome-wide association studies revealed an association between a locus at 10q11, downstream from CXCL12, and myocardial infarction (MI). However, the relationship among plasma CXCL12, cardiovascular disease (CVD) risk factors, incident MI, and death is unknown. Methods and results We analysed study-entry plasma CXCL12 levels in 3687 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a prospective study of cardiovascular and kidney outcomes in chronic kidney disease (CKD) patients. Mean follow-up was 6 years for incident MI or death. Plasma CXCL12 levels were positively associated with several cardiovascular risk factors (age, hypertension, diabetes, hypercholesterolaemia), lower estimated glomerular filtration rate (eGFR), and higher inflammatory cytokine levels (P < 0.05). In fully adjusted models, higher study-entry CXCL12 was associated with increased odds of prevalent CVD (OR 1.23; 95% confidence interval 1.14, 1.33, P < 0.001) for one standard deviation (SD) increase in CXCL12. Similarly, one SD higher CXCL12 increased the hazard of incident MI (1.26; 1.09,1.45, P < 0.001), death (1.20; 1.09,1.33, P < 0.001), and combined MI/death (1.23; 1.13-1.34, P < 0.001) adjusting for demographic factors, known CVD risk factors, and inflammatory markers and remained significant for MI (1.19; 1.03,1.39, P = 0.01) and the combined MI/death (1.13; 1.03,1.24, P = 0.01) after further controlling for eGFR and urinary albumin: creatinine ratio. Conclusions In CKD, higher plasma CXCL12 was associated with CVD risk factors and prevalent CVD as well as the hazard of incident MI and death. Further studies are required to establish if plasma CXCL12 reflect causal actions at the vessel wall and is a tool for genomic and therapeutic trials.
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