期刊
EUROPEAN HEART JOURNAL
卷 33, 期 8, 页码 1007-1016出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehr465
关键词
Automated quantification; Computed tomography; Coronary plaque; Intravascular ultrasound; Registration
资金
- Dutch Heart Foundation [2006T102, 2007B223]
- Dutch Technology Foundation STW (Utrecht, the Netherlands)
- applied science division of NWO
- Ministry of Economic Affairs [10084]
- Medtronic
- Boston Scientific
- Edwards Lifesciences
- Lantheus medical imaging
- St Jude Medical
- GE Healthcare
- Astellas
- Astra-Zeneca
- Biotronik
- Bristol Myers Squibb
- Cordis
- Daiichi Sankyo
- Lilly
- Genzyme
- Merck-Schering-Plough
- Pfizer
- Orbus Neich
- Novartis
- Roche
- Servier
- Netherlands Heart Foundation
- Interuniversity Cardiology Institute of the Netherlands
- European Community
- SenterNovem
- Ministry of Economic Affairs, The Hague, the Netherlands
- project ADVANCE ISO 44070
- Dutch Technology Foundation STW, Utrecht, the Netherlands [10084]
Aims Previous studies have used semi-automated approaches for coronary plaque quantification on multi-detector row computed tomography (CT), while an automated quantitative approach using a dedicated registration algorithm is currently lacking. Accordingly, the study aimed to demonstrate the feasibility and accuracy of automated coronary plaque quantification on cardiac CT using dedicated software with a novel 3D coregistration algorithm of CT and intravascular ultrasound (IVUS) data sets. Methods and results Patients who had undergone CT and IVUS were enrolled. Automated lumen and vessel wall contour detection was performed for both imaging modalities. Dedicated automated quantitative software (QCT) with a unique registration algorithm was used to fuse a complete IVUS run with a CT angiography volume using true anatomical markers. At the level of the minimal lumen area (MLA), percentage lumen area stenosis, plaque burden, and degree of remodelling were obtained on CT. Additionally, mean plaque burden was assessed for the whole coronary plaque. At the identical level within the coronary artery, the same variables were derived from IVUS. Fifty-one patients (40 men, 58 11 years, 103 coronary arteries) with 146 lesions were evaluated. Quantitative computed tomography and IVUS showed good correlation for MLA (n 146, r 0.75, P 0.001). At the level of the MLA, both techniques were well-correlated for lumen area stenosis (n 146, r 0.79, P 0.001) and plaque burden (n 146, r 0.70, P 0.001). Mean plaque burden (n 146, r 0.64, P 0.001) and remodelling index (n 146, r 0.56, P 0.001) showed significant correlations between QCT and IVUS. Conclusion Automated quantification of coronary plaque on CT is feasible using dedicated quantitative software with a novel 3D registration algorithm.
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