期刊
ACS NANO
卷 10, 期 1, 页码 1170-1181出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b06487
关键词
nanodiamond; endothelial cells; vascular barrier leakiness; cancer drug delivery; nanomedicine
类别
资金
- Singapore Ministry of Education Academic Research grant [R-279-000-418-112]
- World Future Foundation (WFF) PhD Prize in Environmental and Sustainability Research
Cancer nanomedicine vehicles are required to cross the vascular barrier to reach the tumor site in order to ensure the successful delivery of their therapeutic load. Here, nanodiamond (ND) variants were shown to induce surface dependent vascular barrier leakiness. The ND-induced leakiness was found to be mediated by the increase in intracellular reactive oxygen species (ROS) and Ca2+. These then in turn triggered the loss in endothelial cell endothelial cell connections of the vascular barrier and also triggered their quasi-stable cytoskeletal remodelling. This ND driven increase in leakiness allowed more doxorubicin drug to penetrate through the vascular barrier to reach the cancer cells. This increase in the doxorubicin penetration subsequently led to an increase in the cancer killing effect. Overall, tuning the vascular barrier leakiness through ND surface group functionalization could provide an alternative strategy for the cancer nanomedicine to traverse across the vascular barrier.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据