期刊
EUROPEAN HEART JOURNAL
卷 31, 期 12, 页码 1502-1510出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehq062
关键词
ALSPAC; Vascular; Children; Endothelial function; Reproducibility
资金
- British Heart Foundation [FS 05/125]
- Medical Research Council
- Wellcome Trust
- UK Department of Health
- Department of the Environment
- DFEE
- National Institutes of Health
- Coronary Artery Disease Research Association (CORDA)
- British Heart Foundation [RG/10/004/28240] Funding Source: researchfish
- Medical Research Council [G9815508, G0600705] Funding Source: researchfish
- MRC [G0600705] Funding Source: UKRI
Aims To assess the feasibility and reproducibility of non-invasive vascular assessment in a childhood population setting and identify the determinants of vascular phenotype in early life. Methods and results We studied 7557 children (age 9.8-12.3 years) participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Six research technicians underwent a 5-month training protocol to enable study of brachial artery endothelial function by flow-mediated dilatation (FMD) and arterial stiffness by carotid to radial pulse wave velocity (PWV) and brachial distensibility [distensibility coefficient (DC)]. Reproducibility studies were performed at the beginning, the middle, and the end of the study. A blinded repeat evaluation of a random selection of 3% of the cohort was also undertaken throughout the study. The effect of anthropometric and environmental factors on each measure was examined. Successful measures were obtained in 88, 95, and 87% of the studied children for FMD, PWV, and DC, respectively. The coefficients of variation between technicians for FMD, PWV, and DC were 10.5, 4.6, and 6.6% at the beginning of the study and reached 7.7, 4.1, and 10% at the end. Baseline vessel diameter and gender were important determinants of all the vascular measures, with a small effect of room and skin temperatures on FMD and PWV. Boys consistently had lower FMD and DC and higher PWV measures (P<0.01 for all). Conclusion Reproducible, high-quality assessments of vascular structure and function in children can be made on a large scale in field studies by suitably trained non-specialist operators. This study provides an invaluable resource for assessing the impact of early influences, genetic, and environmental factors on arterial phenotype.
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