期刊
EUROPEAN HEART JOURNAL
卷 32, 期 3, 页码 316-325出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehq390
关键词
Coronary disease; Metalloproteinases; Platelets
资金
- Fondazione Cassa di Risparmio di Perugia [2007-0130-020]
- Italian Ministry of University and Scientific Research (MIUR) [Prot. 20073KBBHC_003]
- Italian Ministry of Health [RFPS-2006-8-334062]
Aims To investigate whether selected matrix metalloproteinases (MMPs) are released in the coronary circulation of patients with acute coronary syndrome (ACS), whether this release is related to platelet activation, and whether it contributes to sustained platelet activation. Methods and results Blood from the aorta (Ao) and the coronary sinus (Cs) was obtained from 21 controls (non-cardiac chest pain), 24 stable angina (SA), and 30 ACS patients, before performing percutaneous transluminal coronary angioplasty. Selected MMPs, some platelet activation- and atheroma-related markers, and the platelet activation-potentiating activity of plasma were measured. Total MMP-2, active MMP-2, and MMP-9 were released in the coronary circulation of patients with ACS, but not of those with SA or controls. Similarly, transcoronary gradients of beta-thromboglobulin (beta-TG) and platelet factor 4, two platelet-specific proteins, and of soluble CD40L and secretory phospholipase A(2) (sPLA(2)), markers of inflammation and platelet activation, were higher in ACS patients than in the other groups. In contrast, plasma monocyte chemoattractant protein-1, a platelet-unrelated marker of atherogenesis, was not increased in the Cs compared with Ao in any of the groups. Transcoronary gradients of both beta-TG and sPLA(2) correlated with those of total and active MMP-2 in ACS, but not in controls or SA. Plasma from the Cs of ACS patients potentiated platelet activation, an effect suppressed by the specific MMP-2-inhibitor, tissue inhibitor of MMP-2 (TIMP-2). Conclusion Matrix metalloproteinase-2 is released in the coronary circulation of ACS patients, derives in part from activated platelets, and may contribute to sustained intracoronary platelet activation.
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