期刊
EUROPEAN HEART JOURNAL
卷 29, 期 17, 页码 2100-2107出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehn298
关键词
coronary heart disease; epidemiology; cognitive function
资金
- the European Science Foundation
- MRC research professorship
- MRC [G8802774]
- British Heart Foundation
- the British Medical Research Council (MRC)
- the British Heart Foundation
- the British Health and Safety Executive
- the British Department of Health
- he National Heart, Lung, and Blood Institute [HL36310]
- the National Institute on Aging [AG13196]
- the Agency for Health Care Policy and Research [HS06516]
- British Heart Foundation [RG/07/008/23674] Funding Source: researchfish
- Medical Research Council [G8802774, G19/35, G0100222] Funding Source: researchfish
- AGENCY FOR HEALTHCARE RESEARCH AND QUALITY [R01HS006516] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL036310] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG013196, R37AG013196] Funding Source: NIH RePORTER
Aims Some studies show coronary heart disease (CHD) to be a risk factor for cognitive function while others report no association between the two. We examined the effect of CHD history and duration on cognition in a middle-aged population. Methods and results Data come from the Whitehall II study of 10 308 participants (33% women), aged 35-55 years at baseline (Phase 1; 1985-88). CHD events were assessed up to Phase 7 (2002-04) when 5837 participants (28.4% women) undertook six cognitive tests: reasoning, vocabulary, phonemic and semantic fluency, memory and the mini-mental-state-examination (MMSE); standardized to T-scores (mean = 50, standard deviation = 10). Analysis of covariance was used first to model the association between CHD history and cognition and then to examine the effect of time since first CHD event (in the last 5 years, 5-10 years ago, > 10 years ago). Among men, in analyses adjusted for age, education, marital status and medication for cardiovascular disease, CHD history was associated with lower T-scores on reasoning [-1.16; 95% confidence interval (CI) = -2.07, -0.25], vocabulary (-2.11; 95% CI = -3.01, -1.21), and the MMSE (-1.45; 95% CI = -2.42, -0.49). In women, these effects were also evident for phonemic and semantic fluency. Among men, the trend within CHD cases suggested progressively lower scores on reasoning, vocabulary and semantic fluency among those with longer duration of CHD. Conclusion Our findings go some way towards suggesting an association between CHD history and cognitive performance in middle-aged adults.
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