期刊
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
卷 40, 期 8, 页码 969-980出版社
SPRINGER
DOI: 10.1007/s00249-011-0712-5
关键词
Hetero-association; Topotecan; Interceptor-protector mechanism; Competitive binding
类别
Using published in vitro data on the dependence of the percentage of apoptosis induced by the anticancer drug topotecan in a leukaemia cell line on the concentration of added caffeine, and a general model of competitive binding in a system containing two aromatic drugs and DNA, it has been shown to be possible to quantify the relative change in the biological effect just using a set of component concentrations and equilibrium constants of the complexation of the drugs. It is also proposed that a general model of competitive binding and parameterization of that model may potentially be applied to any system of DNA-targeting aromatic drugs under in vitro conditions. The main reasons underpinning the proposal are the general feature of the complexation of aromatic drugs with DNA and their interaction in physiological media via hetero-association.
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