期刊
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
卷 261, 期 3, 页码 213-216出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00406-010-0150-x
关键词
Schizophrenia; Brain; Magnetic resonance imaging (MRI); Diffusion tensor imaging (DTI); Apparent diffusion coefficient (ADC)
资金
- IZKF (Interdisziplinares Zentrum fur klinische Forschung) of the Friedrich-Schiller-University of Jena, Germany
Studies using diffusion tensor imaging (DTI) have shown multifocal reduction in anisotropy of white matter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P < 0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P < 0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not support ADC changes to be a marker of white matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder.
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