期刊
EUROPACE
卷 12, 期 2, 页码 160-172出版社
OXFORD UNIV PRESS
DOI: 10.1093/europace/eup328
关键词
Arrhythmias; Anti-arrhythmia therapy; Anti-arrhythmic drugs; Ablation; Re-entry; Triggered activity; Transgenic; Knockout
资金
- Canadian Institutes of Health Research [MOP 44365, MGP 6957]
- Fondation Leducq [07/CVD/03]
- German Federal Ministry of Education and Research [01Gi0204]
- German Research Foundation [769/1-3]
- MITACS
- Heart and Stroke Foundation of Canada
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. A variety of animal models have been used to study the pathophysiology of AF, including molecular basis, ion-current determinants, anatomical features, and macroscopic mechanisms. In addition, animal models play a key role in the development of new therapeutic approaches, whether drug-based, molecular therapeutics, or device-related. This article discusses the various types of animal models that have been used for AF research, reviews the principle mechanisms governing atrial arrhythmias in each model, and provides some guidelines for model selection for various purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据