期刊
EUKARYOTIC CELL
卷 10, 期 6, 页码 770-775出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.05038-11
关键词
-
资金
- Deutsche Forschungsgemeinschaft [SFB642, ER178/4-1]
- Austrian Science Fund (FWF) [P 23029, W 901] Funding Source: researchfish
Here, we report the identification of a novel hydrolase in Saccharomyces cerevisiae. Ldh1p (systematic name, Ybr204cp) comprises the typical GXSXG-type lipase motif of members of the alpha/beta-hydrolase family and shares some features with the peroxisomal lipase Lpx1p. Both proteins carry a putative peroxisomal targeting signal type1 (PTS1) and can be aligned with two regions of homology. While Lpx1p is known as a peroxisomal enzyme, subcellular localization studies revealed that Ldh1p is predominantly localized to lipid droplets, the storage compartment of nonpolar lipids. Ldh1p is not required for the function and biogenesis of peroxisomes, and targeting of Ldh1p to lipid droplets occurs independently of the PTS1 receptor Pex5p.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据