3.9 Article

African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA

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EUKARYOTIC CELL
卷 7, 期 11, 页码 2012-2016

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AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.00198-08

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  1. National Institutes of Health [R15AI074035-01]
  2. Geneseo Foundation

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It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.

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