期刊
ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY
卷 51, 期 -, 页码 177-191出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSE0510177
关键词
-
资金
- Howard Hughes Medical Institute Funding Source: Medline
Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoea! disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites undergo fundamental changes to survive outside the intestine of their host by differentiating into infective cysts. Encystation entails the synthesis, processing, transport, secretion and extracellular assembly of cyst wall components. To survive within the intestine, Giardia undergoes antigenic variation, a process by which the parasite continuously switches its major surface molecules, allowing the parasite to evade the host's immune response and produce chronic and recurrent infections. The objective of the present chapter is to provide a better understanding of the molecular mechanisms involved in adaptation and differentiation in Giardia, with a particular focus on the process of encystation and antigenic variation of this interesting micro-organism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据