期刊
JOURNAL OF SLEEP RESEARCH
卷 24, 期 4, 页码 364-371出版社
WILEY
DOI: 10.1111/jsr.12291
关键词
circadian rhythms; cognitive speed; cognitive throughput; executive function; neurobehavioural; stroop colour word task; visual search
资金
- NIH [R01-NS41886, M01-RR02635, 1UL1 TR001102, R01-HL081761, R01-HL085705, R01 HL109706, P30-HL101299, R01 HL094806]
- NASA [NCC 9-58]
- National Space Biomedical Research Institute
Sleep inertia, sleep homeostatic and circadian processes modulate cognition, including reaction time, memory, mood and alertness. How these processes influence higher-order cognitive functions is not well known. Six participants completed a 73-day-long study that included two 14-day-long 28-h forced desynchrony protocols to examine separate and interacting influences of sleep inertia, sleep homeostasis and circadian phase on higher-order cognitive functions of inhibitory control and selective visual attention. Cognitive performance for most measures was impaired immediately after scheduled awakening and improved during the first similar to 2-4h of wakefulness (decreasing sleep inertia); worsened thereafter until scheduled bedtime (increasing sleep homeostasis); and was worst at similar to 60 degrees and best at similar to 240 degrees (circadian modulation, with worst and best phases corresponding to similar to 09:00 and similar to 21:00hours, respectively, in individuals with a habitual wake time of 07:00hours). The relative influences of sleep inertia, sleep homeostasis and circadian phase depended on the specific higher-order cognitive function task examined. Inhibitory control appeared to be modulated most strongly by circadian phase, whereas selective visual attention for a spatial-configuration search task was modulated most strongly by sleep inertia. These findings demonstrate that some higher-order cognitive processes are differentially sensitive to different sleep-wake regulatory processes. Differential modulation of cognitive functions by different sleep-wake regulatory processes has important implications for understanding mechanisms contributing to performance impairments during adverse circadian phases, sleep deprivation and/or upon awakening from sleep.
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