期刊
EPL
卷 107, 期 6, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1209/0295-5075/107/68006
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资金
- Brazilian Research Agency CAPES (Rede NanoBioTec)
- Brazilian Research Agency CNPq (INCT-Nano(Bio)Simes, Casadinho/Procad and PNPD)
The charge transport properties of single-stranded microRNAs (miRNAs) chains associated to autism disorder were investigated. The computations were performed within a tight-binding model, together with a transfer matrix technique, with ionization energies and hopping parameters obtained by quantum chemistry method. Current-voltage (I x V) curves of twelve miRNA chains related to the autism spectrum disorders were calculated and analysed. We have obtained both semiconductor and insulator behavior, and a relationship between the current intensity and the autism-related miRNA bases sequencies, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism disorders. Copyright (C) EPLA, 2014
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