期刊
EPILEPSY RESEARCH
卷 100, 期 1-2, 页码 188-193出版社
ELSEVIER
DOI: 10.1016/j.eplepsyres.2012.02.011
关键词
Epilepsy; MRI-negative; Voxel-based morphometric MRI post-processing; Magnetoencephalography; MEG; Stereo-EEG; Focal cortical dysplasia
资金
- Cleveland Clinic Neurological Institute
- Cleveland Clinic Epilepsy Center
- Epilepsy Foundation
- NIH [R01-NS074980, R01-EB009048, DP2-OD006469]
We aim to report on the usefulness of a voxel-based morphometric MRI post-processing technique in detecting subtle epileptogenic structural lesions. The MRI post-processing technique was implemented in a morphometric analysis program (MAP), in a 30-year-old male with pharmacoresistant focal epilepsy and negative MRI. MAP gray white matter junction file facilitated the identification of a suspicious structural lesion in the right frontal opercular area. The electrophysiological data by simultaneously recorded stereo-EEG and MEG confirmed the epileptogenicity of the underlying subtle structural abnormality. The patient underwent a limited right frontal opercular resection, which completely included the area detected by MAP. Surgical pathology revealed focal cortical dysplasia (FCD) type IIb. Post-operatively the patient has been seizure-free for 2 years. This study demonstrates that MAP has promise in increasing the diagnostic yield of MRI reading in challenging patients with non-lesional Mills. The clinical relevance and epileptogenicity of MAP abnormalities in patients with epilepsy have not been investigated systematically; therefore it is important to confirm their pertinence by performing electrophysiological recordings. When confirmed to be epileptogenic, such MAP abnormalities may reflect an underlying subtle cortical dysplasia whose complete resection can lead to seizure-free outcome. (C) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据