期刊
EPILEPSY RESEARCH
卷 99, 期 1-2, 页码 183-186出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2011.10.033
关键词
Valproic acid; Superoxide dismutase 2; Liver dysfunction; Non-alcoholic fatty liver disease; Alanine aminotransferase; gamma-Glutamyltransferase
资金
- Japanese Ministry of Education, Science, Sports and Culture [19590539, 16109006, 22790161]
- Smoking Research Foundation
- Grants-in-Aid for Scientific Research [23510348, 22790161, 24590652, 22890079, 19590539, 24790336] Funding Source: KAKEN
The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy. The Val/Val genotype tended to show elevated alanine aminotransferase levels (odds ratio = 3.5; P=0.056). In addition, an elevated gamma-glutamyltransferase level was associated with the Val/Val genotype (odds ratio = 3.1; P=0.022). The SOD2 Val/Val genotype may therefore contribute to a valproic acid-induced elevation in the serum aminotransferase levels. (C) 2011 Elsevier B.V. All rights reserved.
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