Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers

The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported. The cognitive and psychomotor evaluation consisted of several computerized and paper-and-pencil measures. Eslicarbazepine acetate and oxcarbazepine had similar overall cognitive profiles and did not cause clinically relevant cognitive impairment The incidence of adverse events was lower with eslicarbazepine acetate than with oxcarbazepine. (C) 2010 Published by Elsevier Inc.