期刊
EPILEPSY & BEHAVIOR
卷 18, 期 3, 页码 313-316出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2010.02.013
关键词
EEG-fMRI; Generalized spike and wave; Transient cognitive impairment; Thalamus
资金
- Medical Faculty of the Christian-Albrechts-University Kiel
- Bundesministerium fur Bildung und Forschung (BMBF)
- German Research Foundation (DFG) [SI 1419/2-1]
Generalized spike and wave discharges (GSW) are often accompanied by transitory cognitive impairment (TCI). As a possible neurophysiological correlate of TCI, activation in the thalamus and deactivation in the frontoparietal brain regions associated with GSW were discussed in previous studies which used simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with absence epilepsy. We report on a girl having GSW up to 10 seconds without any clinical concomitants. The girl underwent an EEG-fMRI investigation with simultaneous behavioral testing (continuous performance task). Although GSW repeatedly occurred during the task, no TCI was observed. EEG-fMRI revealed bilateral deactivation in frontoparietal brain areas and activation in the thalamus in association with GSWs. This study challenges the relation between cognitive impairment during absences and the characteristic pattern of thalamic activation and deactivation in frontoparietal areas associated with GSW. (C) 2010 Elsevier Inc. All rights reserved.
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