期刊
EPILEPSY & BEHAVIOR
卷 14, 期 -, 页码 16-25出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2008.09.023
关键词
Brain; Epilepsy; Gene expression; Epileptogenesis; Microarrays; Posttraumatic epilepsy; Status epilepticus
资金
- Academy of Finland
- Sigrid Juselius Foundation
- CURE (Citizens United for Research in Epilepsy)
Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a cascade of molecular and cellular changes that eventually lead to the occurrence of spontaneous seizures. Cellular alterations include neurodegeneration, neurogenesis, axonal sprouting, axonal injury, dendritic remodeling, gliosis, invasion of inflammatory cells, angiogenesis. alterations in extracellular matrix, and acquired channelopathies. Large-scale molecular profiling of epileptogenic tissue has provided information about the molecular pathways that can initiate and maintain cellular alterations. Currently we are learning how these pathways Contribute to postinjury epileptogenesis and recovery process and whether they could be used as treatment targets. (C) 2008 Elsevier Inc. All rights reserved.
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