期刊
JOURNAL OF SEPARATION SCIENCE
卷 39, 期 2, 页码 450-459出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201500927
关键词
beta-Cyclodextrin; Erythromycin; Molecularly imprinted polymers
资金
- Shanghai Natural Science Foundation [11ZR1409100]
- National Natural Science Foundation of China [5110304, U1024209]
- National Basic Research Program of China (973 Program) [2012CB933600]
- Innovation Program of Shanghai Municipal Education Commission [14ZZ060]
- Fundamental Research Funds for the Central Universities [WD1214056]
A type of surface imprinting over magnetic Fe3O4 nanoparticles utilizing erythromycin-A as a template for use in the separation and recovery of erythromycin was developed and investigated. As the intermolecular forces play a key role in the performance of imprinted materials, differential scanning calorimetry, and H-1 NMR spectroscopy was employed to evaluate the interactions between erythromycin and the functional monomer beta-cyclodextrin. To synthesize the surface imprinted polymers, magnetic Fe3O4 nanoparticles, the core materials, were modified with a free radical initiator to initialize polymerization in a grafting from manner. Then using acryloyl-modified beta-cyclodextrin as the functional monomer and ethyleneglycol dimethacrylate as the cross-linker, thin erythromycin-imprinted films were fabricated by the radical-induced graft copolymerization of monomers on the surface of the Fe3O4 nanoparticles. Selectivity experiments showed that the erythromycin-A-imprinted materials had recognition ability toward erythromycin derivatives. Finally, these magnetic molecularly imprinted particles were successfully used for the separation and enrichment of erythromycin from the mother liquor. The recovery, detected by high-performance liquid chromatography and differential pulse voltammetry, approached 97%. The combination of the specific selectivity of the imprinted material and the magnetic separation provided a powerful tool that is simple, flexible, and selective for the separation and recovery of erythromycin.
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