The system epilepsies: A pathophysiological hypothesis

We postulate that system epilepsies (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesisthat some types of epilepsy depend on the dysfunction of specific neural systemsare reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.