期刊
EPILEPSIA
卷 52, 期 -, 页码 19-20出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1528-1167.2011.03227.x
关键词
Astrocytes; Microglia; Serum albumin; Transforming growth factor beta
资金
- Sonderforschungsbereich [TR3]
- Israel Science Foundation
- Binational US-Israel Science Foundation
- National Institute for Neurological Disorders and Stroke
Status epilepticus is often associated with endothelial dysfunction and increased vessels permeability. We discuss here the direct role of blood-brain barrier (BBB) dysfunction in epileptogenesis and brain damage. On the cellular level, astrocytes respond early to the efflux of serum proteins in the presence of dysfunctional BBB, with activation of the innate immune system and disturbed homeostasis of extracellular potassium and glutamate. In turn, there is enhanced excitability of neurons and altered network connectivity. Transforming growth factor beta (TGF-beta) signaling appears to be a potential new target for the prevention of epileptogenesis and secondary damage following status epilepticus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据