期刊
EPILEPSIA
卷 52, 期 -, 页码 67-69出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1528-1167.2011.03242.x
关键词
Interleukin-1 receptor/Toll-like receptor; ICE/Caspase-1; IL-1 beta
资金
- Fondazione Monzino
- Parents Against Childhood Epilepsy (PACE)
- Cariplo Foundation
- NeuroGlia [EU-FP7-project 202167]
Experimental and clinical findings have shown in the past decade that specific proinflammatory mediators and their cognate receptors are upregulated in epileptic brain tissue. In particular, the IL-1 receptor (R)/Toll-like receptor (TLR) signaling pathways are activated in experimental models of seizures and in human epileptic tissue from drug-resistant patients. Pharmacological targeting of these proinflammatory pathways using selective receptor antagonists, or the use of trans-genic mice with perturbed cell signaling, demostrated that the activation of IL-1R type 1 and TLR4 by their respective endogenous ligands, i.e., interleukin (IL)-1b and High Mobility Group Box 1, is implicated in the precipitation and recurrence of experimentally induced seizures in rodents. This evidence highlights a new target system for pharmacological intervention to inhibit seizures by interfering with mechanisms involved in their genesis and recurrence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据