期刊
EPILEPSIA
卷 51, 期 8, 页码 1348-1358出版社
WILEY
DOI: 10.1111/j.1528-1167.2010.02654.x
关键词
Polyunsaturated fatty acids; PUFA; omega-3 (n-3); Docosahexaenoic acid; Seizures; Epilepsy; Ketogenic diet; Inflammation; Ion channel; Peroxisome proliferator-activated receptors
P>Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiologic processes in the brain. There is some evidence suggesting that PUFAs-and particularly omega-3 PUFAs-may have anticonvulsant effects, both in humans and in animals. In the present review, we assess the evidence related to the antiseizure properties of the n-3 PUFAs, discuss their possible mechanism(s) of action, and make recommendations for future clinical trials. In general, the available data from cell cultures and whole animal studies support the idea that the n-3 PUFAs have antiseizure properties. Future clinical trials involving the n-3 PUFAs should involve higher doses and longer periods of administration in order to definitively assess their possible antiseizure effects.
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