期刊
EPILEPSIA
卷 51, 期 3, 页码 473-477出版社
WILEY
DOI: 10.1111/j.1528-1167.2009.02287.x
关键词
Anti-VGKC antibody; Seizure disorder; Limbic encephalitis; Encephalopathy
资金
- National Center for Research Resources (NCRR) [TL1 RR024129-01]
- National Institutes of Health (NIH)
- NIH/NIA [K23 AG 21989, R01-AG031189]
- Michael J. Homer Family Fund
P>Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti-voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti-voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据