期刊
EPILEPSIA
卷 50, 期 7, 页码 1816-1820出版社
WILEY
DOI: 10.1111/j.1528-1167.2009.02047.x
关键词
Absence epilepsy; Cortical focus; Electrocorticogram; GAERS; Ictogenesis; In vivo intracellular recording
资金
- Agence Nationale de la Recherche (ANR) [RO6275CS]
- Institut National de la Sante et de la Recherche Medicale
- Fondation Francaise pour la Recherche sur l'Epilepsie
- Ligue Francaise Contre l'Epilepsie
P>Absence epilepsy is a form of generalized epilepsy commonly seen in children. The neuronal process by which ethosuximide (ETX), a first choice anti-absence drug, prevents absence seizures is still unresolved. Recent clinical findings have indicated that focal cortical regions are involved during absence seizures. Consistently, it has been shown in genetic models of absence epilepsy that epileptic discharges arise from a delimited region of the cerebral cortex. Here, we made simultaneous in vivo electrocorticographic and intracellular recordings from the cortical focus of the genetic absence epilepsy rat from Strasbourg and examined the effects of systemic injection of ETX at a therapeutic concentration. We show that the interruption of seizures by ETX is correlated with a recovery, in the hyperactive focus neurons, of physiologic values of membrane potential, firing rate, and pattern, as measured in analogous neurons from nonepileptic rats. These data suggest that the anti-absence action of ETX results from the conversion of ictogenic cortical neurons into normal cortical neurons.
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