期刊
EPILEPSIA
卷 49, 期 -, 页码 114-116出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1528-1167.2008.01853.x
关键词
Glioma; Vascularity; Caloric restriction; Ketone bodies; Metabolic control analysis; Angiogenesis; Apoptosis; Inflammation
资金
- NIH [HD39722, NS055195, CA102135]
- American Institute of Cancer Research
- Boston College Expense Fund
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD039722] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA102135] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R56NS055195, R01NS055195] Funding Source: NIH RePORTER
Information is presented on the calorically restricted ketogenic diet (CRKD) as an alternative therapy for brain cancer. In contrast to normal neurons and glia, which evolved to metabolize ketone bodies as an alternative fuel to glucose under energy-restricted conditions, brain tumor cells are largely glycolytic due to mitochondrial defects and have a reduced ability to metabolize ketone bodies. The CRKD is effective in managing brain tumor growth in animal models and in patients, and appears to act through antiangiogenic, anti-inflammatory, and proapoptotic mechanisms.
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