期刊
EPIGENETICS
卷 9, 期 5, 页码 653-657出版社
LANDES BIOSCIENCE
DOI: 10.4161/epi.28297
关键词
histone modifications; chromatin domain; DNA packaging; chromatin fiber; nucleosome mobility; 3D genome organization
资金
- Presidium of the Russian Academy of Sciences
- RFBR [12-04-93109, 12-04-0036, 14-04-00010]
- Dmitri Zimin's foundation Dynasty
Several hierarchical levels of DNA packaging are believed to exist in chromatin, starting from a 10-nm chromatin fiber that is further packed into a 30-nm fiber. Transitions between the 30-nm and 10-nm fibers are thought to be essential for the control of chromatin transcriptional status. However, recent studies demonstrate that in the nuclei, DNA is packed in tightly associated 10-nm fibers that are not compacted into 30-nm fibers. Additionally, the accessibility of DNA in chromatin depends on the local mobility of nucleosomes rather than on decompaction of chromosome regions. These findings argue for reconsidering the hierarchical model of chromatin packaging and some of the basic definitions of chromatin. In particular, chromatin domains should be considered as three-dimensional objects, which may include genomic regions that do not necessarily constitute a continuous domain on the DNA chain.
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