期刊
EPIGENETICS
卷 8, 期 1, 页码 16-22出版社
LANDES BIOSCIENCE
DOI: 10.4161/epi.23331
关键词
chromatin modifier; methylation; histones; transcription factors; cancer; differentiation; gene expression; transcription
资金
- National Medical Research Council
- A*STAR Singapore Stem Cell Consortium
Lysine methylation of histone and non-histone substrates by the methyltransferase G9a is mostly associated with transcriptional repression. Recent studies, however, have highlighted its role as an activator of gene expression through mechanisms that are independent of its methyltransferase activity. Here we review the growing repertoire of molecular mechanisms and substrates through which G9a regulates gene expression. We also discuss emerging evidence for its wide-ranging functions in development, pluripotency, cellular differentiation and cell cycle regulation that underscore the complexity of its functions. The deregulated expression of G9a in cancers and other human pathologies suggests that it may be a viable therapeutic target in various diseases.
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