相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Global DNA methylation in old subjects is correlated with frailty
Dina Bellizzi et al.
AGE (2012)
Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis
Kimberly Larson et al.
PLOS GENETICS (2012)
Epigenetic Control of Aging
Ursula Munoz-Najar et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
L. Chouliaras et al.
BRAIN BEHAVIOR AND IMMUNITY (2011)
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner, and follow expression of p16ink4a
Martin Kosar et al.
CELL CYCLE (2011)
Unphosphorylated STAT and heterochromatin protect genome stability
Shian-Jang Yan et al.
FASEB JOURNAL (2011)
SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
Lirong Peng et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Camilla Burnett et al.
NATURE (2011)
A damage limitation exercise
Andrejs Ivanov et al.
NATURE CELL BIOLOGY (2011)
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
Raffaella Di Micco et al.
NATURE CELL BIOLOGY (2011)
Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation
Anton Wutz
NATURE REVIEWS GENETICS (2011)
p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms
Yuanyuan Li et al.
PLOS ONE (2011)
Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8
Chun Mei Wang et al.
BIOGERONTOLOGY (2010)
Increasing healthy lifespan by suppressing aging in our lifetime Preliminary proposal
Mikhail V. Blagosklonny
CELL CYCLE (2010)
The role of insulin/IGF-like signaling in C. elegans longevity and aging
Rachel Kaletsky et al.
DISEASE MODELS & MECHANISMS (2010)
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression
Yuanyuan Li et al.
FASEB JOURNAL (2010)
Calorie restriction reduces rDNA recombination independently of rDNA silencing
Michele Riesen et al.
AGING CELL (2009)
Chromatin modifications: The driving force of senescence and aging?
Teresa DiMauro et al.
AGING-US (2009)
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
Fabio Demontis et al.
DEVELOPMENT (2009)
Calorie restriction and the exercise of chromatin
Alejandro Vaquero et al.
GENES & DEVELOPMENT (2009)
Life can be stressful without ATR
Mark O'Driscoll
NATURE GENETICS (2009)
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
Matilde Murga et al.
NATURE GENETICS (2009)
Decline in genomic DNA methylation through aging in a cohort of elderly subjects
Valentina Bollati et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
Hanane Agherbi et al.
PLOS ONE (2009)
Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation
Jamy C. Peng et al.
PLOS GENETICS (2009)
The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies
Annely Brandt et al.
AGING CELL (2008)
Epigenetic control of rDNA loci in response to intracellular energy status
Akiko Murayama et al.
CELL (2008)
Aging by epigenetics - A consequence of chromatin damage?
John M. Sedivy et al.
EXPERIMENTAL CELL RESEARCH (2008)
Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation
Min Shi et al.
IMMUNITY (2008)
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
Paola Scaffidi et al.
NATURE CELL BIOLOGY (2008)
Ageing and the regulation of protein synthesis: a balancing act?
Nektarios Tavernarakis
TRENDS IN CELL BIOLOGY (2008)
Canonical and non-canonical JAK-STAT signaling
Willis X. Li
TRENDS IN CELL BIOLOGY (2008)
Facultative heterochromatin: Is there a distinctive molecular signature?
Patrick Trojer et al.
MOLECULAR CELL (2007)
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination
Roberta Benetti et al.
JOURNAL OF CELL BIOLOGY (2007)
Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process
Asumthia S. Jeyapalan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Epigenetics and aging: the targets and the marks
Mario F. Fraga et al.
TRENDS IN GENETICS (2007)
Longevity determined by developmental arrest genes in Caenorhabditis elegans
Di Chen et al.
AGING CELL (2007)
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
Peter D. Adams
GENE (2007)
Cellular senescence in cancer and aging
Manuel Collado et al.
CELL (2007)
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells
Xiaofen Ye et al.
MOLECULAR CELL (2007)
Deletion of the developmentallv essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
Yaroslava Ruzankina et al.
CELL STEM CELL (2007)
Cellular senescence and chromatin organisation
M. Narita
BRITISH JOURNAL OF CANCER (2007)
Molecular dissection of formation of senescence-associated heterochromatin foci
Rugang Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
SIRT1 promotes DNA repair activity and deacetylation of Ku70
Jaemin Jeong et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2007)
Chromatin modifications and their function
Tony Kouzarides
CELL (2007)
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
Roberta Benetti et al.
NATURE GENETICS (2007)
Role of insulin-like signalling in Drosophila lifespan
Maria E. Giannakou et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
The role of nuclear architecture in genomic instability and ageing
Philipp Oberdoerffer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability
Jamy C. Peng et al.
NATURE CELL BIOLOGY (2007)
Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia
Kanji So et al.
CANCER SCIENCE (2006)
Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction
Marcia C. Haigis et al.
GENES & DEVELOPMENT (2006)
The regulation of INK4/ARF in cancer and aging
William Y. Kim et al.
CELL (2006)
Progressive loss of SIRT1 with cell cycle withdrawal
Tsutomu Sasaki et al.
AGING CELL (2006)
JAK signaling globally counteracts heterochromatic gene silencing
Song Shi et al.
NATURE GENETICS (2006)
ΔNp63α overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
Matthias Sommer et al.
CELL CYCLE (2006)
Sirtuins in aging and age-related disease
Valter D. Longo et al.
CELL (2006)
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Dale K. Shumaker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Lamin A-dependent nuclear defects in human aging
P Scaffidi et al.
SCIENCE (2006)
DNA methyltransferases control telomere length and telomere recombination in mammalian cells
S Gonzalo et al.
NATURE CELL BIOLOGY (2006)
Cellular senescence in aging primates
U Herbig et al.
SCIENCE (2006)
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
Kevin Pruitt et al.
PLOS GENETICS (2006)
Regulation of growth arrest in senescence: Telomere damage is not the end of the story
U Herbig et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2006)
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
M Kaeberlein et al.
SCIENCE (2005)
Age-related changes of nuclear architecture in Caenorhabditis elegans
E Haithcock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The diverse functions of histone lysine methylation
C Martin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
HST2 mediates SIR2-independent life-span extension by catorie restriction
DW Lamming et al.
SCIENCE (2005)
Oncogene-induced senescence as an initial barrier in lymphoma development
M Braig et al.
NATURE (2005)
The signals and pathways activating cellular senescence
I Ben-Porath et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)
Epigenetic mechanism of rRNA gene silencing: Temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation
R Santoro et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Calorie restriction -: the SIR2 connection
L Guarente et al.
CELL (2005)
DNA repair, genome stability, and aging
DB Lombard et al.
CELL (2005)
Age-related human small intestine methylation: evidence for stem cell niches
Jung Yeon Kim et al.
BMC MEDICINE (2005)
Toward a unified theory of caloric restriction and longevity regulation
DA Sinclair
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
RG Zhang et al.
DEVELOPMENTAL CELL (2005)
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
HY Cohen et al.
MOLECULAR CELL (2004)
Sir2-independent life span extension by calorie restriction in yeast
M Kaeberlein et al.
PLOS BIOLOGY (2004)
被撤回的出版物: Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly (Retracted article. See vol. 73, pg. 1084, 2019)
SA Sarraf et al.
MOLECULAR CELL (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
Gene regulation and DNA damage in the ageing human brain
T Lu et al.
NATURE (2004)
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
B Rogina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
PG Pelicci
JOURNAL OF CLINICAL INVESTIGATION (2004)
The Sir2 family of protein deacetylases
G Blander et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2004)
DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
TM Geiman et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span
JT Sun et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
H Van Remmen et al.
PHYSIOLOGICAL GENOMICS (2003)
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts
MA Casillas et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Heterochromatin and epigenetic control of gene expression
SIS Grewal et al.
SCIENCE (2003)
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
CT Murphy et al.
NATURE (2003)
Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples
T Waki et al.
ONCOGENE (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
M Narita et al.
CELL (2003)
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
RM Anderson et al.
NATURE (2003)
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
F Fuks et al.
NUCLEIC ACIDS RESEARCH (2003)
DAF-16 target genes that control C-elegans life-span and metabolism
SS Lee et al.
SCIENCE (2003)
Lifespan extension in C-elegans by a molecular chaperone dependent upon insulin-like signals
GA Walker et al.
AGING CELL (2003)
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
KK Wong et al.
NATURE (2003)
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
MC Wang et al.
DEVELOPMENTAL CELL (2003)
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription
R Santoro et al.
NATURE GENETICS (2002)
Cancer and aging: a model for the cancer promoting effects of the aging stroma
A Krtolica et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)
Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
B Sarg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
SJ Lin et al.
NATURE (2002)
Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts
N Lopatina et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Does oxidative damage to DNA increase with age?
ML Hamilton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
F Fuks et al.
EMBO JOURNAL (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
HA Tissenbaum et al.
NATURE (2001)
Oxidants, oxidative stress and the biology of ageing
T Finkel et al.
NATURE (2000)
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
SJ Lin et al.
SCIENCE (2000)
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
MR Rountree et al.
NATURE GENETICS (2000)
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
KD Robertson et al.
NATURE GENETICS (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)
The HP1 protein family: getting a grip on chromatin
JC Eissenberg et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2000)
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
F Fuks et al.
NATURE GENETICS (2000)
分享论文
