期刊
EPIGENETICS
卷 6, 期 8, 页码 971-978出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.6.8.16793
关键词
DNA methylation; psychiatry; development; epidemiology; environment
资金
- Canadian Institutes of Health Research
- National Institute of Cancer Research Canada
- US National Institutes of Health (National Institute of Child Health and Human Development)
- McGill University
- Canadian Institute for Advanced Research
Although epidemiological data provides evidence that there is an interaction between genetics (nature) and the social and physical environments (nurture) in human development; the main open question remains the mechanism. The pattern of distribution of methyl groups in DNA is different from cell-type to cell type and is conferring cell specific identity on DNA during cellular differentiation and organogenesis. This is an innate and highly programmed process. However, recent data suggests that DNA methylation is not only involved in cellular differentiation but that it is also involved in modulation of genome function in response to signals from the physical, biological and social environments. We propose that modulation of DNA methylation in response to environmental cues early in life serves as a mechanism of life-long genome adaptation that molecularly embeds the early experiences of a child (nurture) in the genome (nature). There is an emerging line of data supporting this hypothesis in rodents, non-human primates and humans that will be reviewed here. However, several critical questions remain including the identification of mechanisms that transmit the signals from the social environment to the DNA methylation/demethylation enzymes.
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