期刊
EPIGENETICS
卷 6, 期 2, 页码 153-160出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.6.2.13589
关键词
histones; chromatin; tyrosine phosphorylation; genomic instability; DNA damage; DNA repair; apoptosis; ubiquitylation; proteolysis; cancer
资金
- Florida Department of Health [07BN-02]
- NIH [R21 MH081046]
Histones were discovered over a century ago and have since been found to be the most extensively post-translationally modified proteins, although tyrosine phosphorylation of histones had remained elusive until recently. The year 2009 proved to be a landmark year for histone tyrosine (Y) phosphorylation as five research groups independently discovered this modification. Three groups describe phosphorylation of Y142 in the variant histone H2A. X, where it may be involved in the cellular decision making process to either undergo DNA repair or apoptosis in response to DNA damage. Further, one group suggests that phosphorylation of histone H3 on Y99 is crucial for its regulated proteolysis in yeast, while another found that Y41 phosphorylation modulates chromatin architecture and oncogenesis in mammalian cells. These pioneering studies provide the initial conceptual framework for further analyses of the diverse roles of tyrosine phosphorylation on different histones, with far reaching implications for human health and disease.
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