期刊
EPIGENETICS
卷 5, 期 4, 页码 255-266出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/epi.5.4.11518
关键词
meiosis; DNA double-strand break repair; chromosome pairing; MSCI; sex chromosomes; MSUC; gamma H2AX; histone modification
资金
- Netherlands Organization for Scientific Research (NWO) through ALW [VIDI 864.05.003]
Chromosome pairing and synapsis during meiotic prophase requires the formation and repair of DNA double-strand breaks (DSBs) by the topoisomerase-like enzyme SPO11. Chromosomes, or chromosomal regions, that lack a pairing partner, such as the largely heterologous X and Y chromosomes, show delayed meiotic DSB repair and are transcriptionally silenced. Herein, we review meiosis-specific aspects of DSB repair in relation to homology recognition and meiotic silencing of heterologous regions. We propose a dynamic interplay between progression of synapsis and persistent meiotic DSBs. Signaling from these persistent breaks could inhibit heterologous synapsis and stimulate meiotic silencing of the X and Y chromosomes.
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