4.6 Article

Arsenic in Drinking Water and Adult Mortality A Population-based Cohort Study in Rural Bangladesh

期刊

EPIDEMIOLOGY
卷 20, 期 6, 页码 824-830

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EDE.0b013e3181bb56ec

关键词

-

资金

  1. Swedish International Development Agency (Sida) [U11 BB/1.5.-3, 1998-05440, U11 BB/1.5.-3/A]
  2. World Health Organization (WHO) [SE/01/037664]
  3. United States Agency for International Development (USAID) [388-G-00-02-00125-00]

向作者/读者索取更多资源

Background: Arsenic is a potent human carcinogen and toxicant. Elevated concentration of arsenic in drinking water is a major public-health problem worldwide. We evaluated risks of adult mortality (due to cancer and cardiovascular and infectious diseases) in relation to arsenic exposure through drinking water. Methods: A cohort analysis was applied to survival data prospectively collected during 1991-2000 in a health and demographic surveillance system in Matlab, Bangladesh, where tubewells were installed beginning in the early 1970s. A total of 115,903 persons aged 15 or more years on I January 1991 were available for analysis. In this period, 9015 people died and 22,488 were lost to follow-up. Arsenic exposure data were derived from a survey in 2002-2003 of past and current water use and arsenic concentrations in all tubewells. We estimated risk of excess mortality in relation to arsenic exposure, using proportional hazards models. Results: Even at low levels (10-49 mu g/L) of arsenic in drinking water, we observed increased risk of death due to all nonaccidental causes (hazard ratio = 1.16 [95% confidence interval = 1.06-1.26]). Increased risks at exposure of 50-149 mu g/L were observed for death due to cancers (1.44 [1.06-1.95]), cardiovascular disease (1.16 [0.96-1.40]), and infectious diseases (1.30 [1.13-1.49]). We observed clear dose-response relationships for each of these causes. Conclusions: Arsenic exposure through drinking water has generated excess adult mortality after 20-30 years of exposure.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据