期刊
EPIDEMIOLOGIC REVIEWS
卷 36, 期 1, 页码 137-147出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/epirev/mxt012
关键词
bone mineral density; osteoporosis risk; ovulatory disturbances; premenopause; progesterone
Subclinical ovulatory disturbances (anovulation or short luteal phases within normal-length menstrual cycles) indicate lower progesterone-to-estrogen levels. Given that progesterone plays a bone formation role, subclinical ovulatory disturbances may be associated with bone loss or less than expected bone gain. Our purpose was to perform a meta-analysis of prospective studies in healthy premenopausal women to determine the overall relationship of subclinical ovulatory disturbances to change in bone mineral density. Two reviewers independently identified from serial literature searches 6 studies meeting inclusion criteria: a 2-year study in 114 young adult women, 20062009, Vancouver, Canada; a 2-year study in 189 premenopausal women, 20002005, Toronto, Canada; a single-cycle study in 14 young women, 19961997, Melbourne, Australia; an 18-month study in 53 women, 19901995, Santa Clara, California; a 4-year study in 27 women, 19881995, Vancouver, Canada; and a 1-year study in 66 women, 19851988, Vancouver, Canada. This meta-analysis included a combined sample size of 473 observations in 436 premenopausal women studied over 14 years and aged 1447 years. The percentage of women with ovulatory disturbances varied significantly from 13 to 82. Women with more frequent ovulatory disturbances had more negative percentage changes in spine bone mineral density (weighted mean difference 0.86; P 0.040) for random-effects analysis. There was significant heterogeneity among these 6 studies (I-2 80). In summary, these data show that regularly menstruating women with more frequent ovulatory disturbances experience more negative changes in bone (approximately 0.9 per year). These cycles with silent estrogen/progesterone imbalance may be clinically important.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据