期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 37, 期 2, 页码 571-579出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2014.01.011
关键词
Davallia cylindrica; Flavonoids; Antioxidant; Anticancer; Acetylcholinesterase inhibitor
资金
- National Natural Science Fund of China [31301442]
- Natural Science Foundation of Shanghai [13ZR1429700]
- Leading Academic Discipline Project and Key Project of Shanghai Municipal Education Commission [12ZZ128]
- Program of the Shanghai Normal University [SK201231]
The flavonoids profiles and bioactivities of flavonoids-rich extract from Davallia cylinclrica Ching were investigated. The total flavonoids content in D. cylindrica was determined as about 164.41 mg/g. The main flavonoids in D. cylindrica were tentatively identified as quercetin-3-O-rutinoside, quercetin 7-O-glucoside, quercetin 7-O-glucoside, kaempferol 3-O-rutinoside, and quercitrin by UV and ESI-MS spectra. Flavonoids-rich extract (0.258 mg/ml) from D. cylindrica showed similar or higher free radical (O-2(-), DPPH center dot and ABTS center dot) scavenging potential with that of rutin (0.25 mg/ml). The reducing power of flavonoids-rich extract (0.258 mg/ml) was slightly stronger than that of 0.25 mg/ml rutin. The flavonoids extract from D. cylindrica exhibited cytotoxic effects on A549 cells. It exhibited a dose-dependent inhibition against acetylcholinesterase. (C) 2014 Elsevier B.V. All rights reserved.
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