期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 38, 期 1, 页码 297-304出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2014.06.007
关键词
BDE209; Antioxidant enzymes; Lipid peroxidation; Hydroxyl radical; Eisenia fetida
资金
- National Natural Science Foundation of China [41371467, 40901148, 21307030]
- Science and Technology Committee Research Program of Shanghai [12DZ0502700]
- National Environmental Protection Public Welfare Science and Technology Research Program of China [201409037, 201409076, 201309047, 201309030]
- Major State Basic Research Development Program of China [2011CB200904]
- Scientific Project on Treatment and Control of Water Pollution [2014ZX07104006]
- State Scholar Fund of China Scholar Council [201208310075]
Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor incubation tests were performed systematically on control and contaminated soil samples to determine the effects of BDE209 on the antioxidant system of earthworm Eisenia fetida. The results showed that compared to the controls, superoxide dismutase (SOD) activities in all treated groups were elevated significantly after 21 and 28 days exposure; catalase (CAT) activities were much higher in all tests during the entire exposure period; peroxidase (POD) and glutathione-s-transferase (GST) activities generally decreased and indicated contrary response trend; the total antioxidant capacity (T-AOC) after exposure to low level of BDE209 (1 mg kg(-1)) was induced, whereas at 10 and 100 mg kg(-1) concentrations it showed suppression status; electron paramagnetic resonance (EPR) spectra suggested that hydroxyl radicals ((OH)-O-center dot) in earthworms were significantly induced by BDE209; the changes in malondialdehyde (MDA) contents suggested that reactive oxygen species (ROS) might lead to cellular lipid peroxidation in earthworms. The results of these observations suggested that severe oxidative stress occurred in E. fetida, and it may play an important role in inducing the BDE209 toxicity to earthworms. (C) 2014 Elsevier B.V. All rights reserved.
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